| 1. Ronde | 18.07.2021 | Santa Fe | - | Deportivo Cali | 1:2 |  |
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| 2. Ronde | 25.07.2021 | Atlético Bucaramanga | - | Santa Fe | 4:3 | |
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| 3. Ronde | 04.08.2021 | Santa Fe | - | Atlético Nacional | 0:1 | ||||
| 4. Ronde | 08.08.2021 | Millonarios | - | Santa Fe | 0:1 | ||||
| 5. Ronde | 17.08.2021 | Santa Fe | - | La Equidad | 0:2 | |
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| 6. Ronde | 21.08.2021 | Deportivo Pereira | - | Santa Fe | 1:1 | |
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| 7. Ronde | 30.08.2021 | Santa Fe | - | América de Cali | 1:1 | ||||
| 8. Ronde | 05.09.2021 | Independiente Medellín | - | Santa Fe | 0:0 | ||||
| 9. Ronde | 12.09.2021 | Santa Fe | - | Alianza Petrolera | 1:1 | ||||
| 10. Ronde | 20.09.2021 | Deportivo Pasto | - | Santa Fe | 0:1 | ||||
| 11. Ronde | 25.09.2021 | Santa Fe | - | Envigado FC | 3:1 | |
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| 12. Ronde | 02.10.2021 | Deportes Tolima | - | Santa Fe | 0:0 | ||||
| 13. Ronde | 12.10.2021 | Patriotas FC | - | Santa Fe | 0:1 | ||||
| 14. Ronde | 18.10.2021 | Santa Fe | - | Millonarios | 0:2 | |
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| 15. Ronde | 25.10.2021 | Atlético Huila | - | Santa Fe | 1:2 | |
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| 17. Ronde | 02.11.2021 | Deportes Quindío | - | Santa Fe | 1:1 | ||||
| 18. Ronde | 07.11.2021 | Santa Fe | - | Atlético Junior | 1:1 | ||||
| 19. Ronde | 16.11.2021 | Once Caldas | - | Santa Fe | 2:1 | ||||
| 20. Ronde | 21.11.2021 | Santa Fe | - | Águilas Doradas | 0:1 |
Colombia