| 1. Ronde | 01.07.2021 | FC Sheriff | - | FC Bălţi | 0:1 |  |
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| 4. Ronde | 31.07.2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 10. Ronde | 19.09.2021 | FC Zimbru | - | FC Sheriff | 1:1 | ||||
| 11. Ronde | 22.09.2021 | FC Sheriff | - | FC Floreşti | 4:0 | ||||
| 12. Ronde | 25.09.2021 | Dinamo-Auto | - | FC Sheriff | 0:7 | ||||
| 14. Ronde | 16.10.2021 | FC Sheriff | - | FC Sfîntul Gheorghe | 4:0 | ||||
| 15. Ronde | 23.10.2021 | FC Sheriff | - | FC Bălţi | 2:0 | ||||
| 17. Ronde | 06.11.2021 | FC Sheriff | - | FC Zimbru | 6:0 | ||||
| 18. Ronde | 20.11.2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 19. Ronde | 28.11.2021 | FC Sheriff | - | Dinamo-Auto | 7:0 | ||||
| 3. Ronde | 11.12.2021 | FC Sheriff | - | FC Zimbru | 4:0 | ||||
| 6. Ronde | 01.03.2022 | FC Sheriff | - | FC Milsami | 1:0 | ||||
| 20. Ronde | 13.03.2022 | FC Sheriff | - | FC Milsami | 0:1 | ||||
| 21. Ronde | 19.03.2022 | FC Sfîntul Gheorghe | - | FC Sheriff | 0:3 | ||||
| 22. Ronde | 03.04.2022 | FC Bălţi | - | FC Sheriff | 0:3 | ||||
| 23. Ronde | 08.04.2022 | FC Sheriff | - | CS Petrocub | 1:0 | ||||
| 24. Ronde | 16.04.2022 | FC Zimbru | - | FC Sheriff | 1:1 | ||||
| 26. Ronde | 29.04.2022 | Dinamo-Auto | - | FC Sheriff | 0:3 |
Trinidad & Tobago