| 3. Ronde | 26.09.2021 | Fénix | - | Montevideo City Torque | 1:1 | ||||
| 4. Ronde | 02.10.2021 | Villa Española | - | Fénix | 1:2 | ||||
| 5. Ronde | 10.10.2021 | Fénix | - | Nacional | 1:2 | ||||
| 6. Ronde | 17.10.2021 | Cerrito | - | Fénix | 2:4 | ||||
| 9. Ronde | 31.10.2021 | Fénix | - | Cerro Largo | 1:4 | ||||
| 10. Ronde | 04.11.2021 | Progreso | - | Fénix | 1:0 | ||||
| 14. Ronde | 30.11.2021 | Fénix | - | Boston River | 0:0 | ||||
| 15. Ronde | 04.12.2021 | Montevideo Wanderers | - | Fénix | 1:1 |  |
Uruguay