| 5. Ronde | 06.02.2022 | FAS | - | Santa Tecla FC | 2:0 | ||||
| 6. Ronde | 09.02.2022 | Municipal Limeño | - | FAS | 1:1 | ||||
| 10. Ronde | 27.02.2022 | Luis Ángel Firpo | - | FAS | 2:3 |  |
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| 4. Ronde | 03.03.2022 | Alianza | - | FAS | 1:1 | ||||
| 11. Ronde | 06.03.2022 | FAS | - | Platense Zacatecoluca | 2:1 | ||||
| 12. Ronde | 13.03.2022 | FAS | - | Once Municipal | 0:0 | ||||
| 13. Ronde | 20.03.2022 | CD Águila | - | FAS | 2:0 | ||||
| 16. Ronde | 10.04.2022 | Santa Tecla FC | - | FAS | 1:1 | |
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| 17. Ronde | 13.04.2022 | FAS | - | Municipal Limeño | 1:1 | ||||
| 19. Ronde | 24.04.2022 | FAS | - | Isidro Metapán | 4:1 | ||||
| 20. Ronde | 28.04.2022 | AD Chalatenango | - | FAS | 3:2 | ||||
| 21. Ronde | 01.05.2022 | FAS | - | Luis Ángel Firpo | 0:1 | |
El Salvador