| 6. Ronde | 13.02.2022 | Santa Fe | - | Deportivo Pereira | 1:2 | ||||
| 11. Ronde | 17.03.2022 | Deportivo Pasto | - | Santa Fe | 2:4 | ||||
| 12. Ronde | 22.03.2022 | Santa Fe | - | Atlético Bucaramanga | 3:1 | ||||
| 13. Ronde | 29.03.2022 | Atlético Nacional | - | Santa Fe | 2:1 | ||||
| 14. Ronde | 04.04.2022 | Santa Fe | - | Unión Magdalena | 1:0 |  |
|||
| 15. Ronde | 10.04.2022 | Envigado FC | - | Santa Fe | 1:0 | ||||
| 16. Ronde | 16.04.2022 | Santa Fe | - | Alianza Petrolera | 0:1 |  |
Colombia