| 3. Ronde | 11.09.2021 | Floriana FC | - | Valletta FC | 3:0 | ||||
| 4. Ronde | 18.09.2021 | Valletta FC | - | Gżira United | 0:2 | ||||
| 5. Ronde | 25.09.2021 | Gudja United | - | Valletta FC | 2:0 | ||||
| 6. Ronde | 17.10.2021 | Valletta FC | - | Sirens FC | 3:1 | ||||
| 7. Ronde | 24.10.2021 | Hibernians FC | - | Valletta FC | 1:1 | ||||
| 8. Ronde | 30.10.2021 | Valletta FC | - | St. Luċija FC | 5:3 | ||||
| 9. Ronde | 20.11.2021 | Sliema Wanderers | - | Valletta FC | 0:3 Toeg. |  |
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| 10. Ronde | 27.11.2021 | Valletta FC | - | Mosta FC | 3:1 |  |
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| 11. Ronde | 04.12.2021 | Valletta FC | - | Birkirkara FC | 0:0 | ||||
| 12. Ronde | 13.12.2021 | Valletta FC | - | Hamrun Spartans | 0:1 | ||||
| 13. Ronde | 19.12.2021 | Balzan FC | - | Valletta FC | 2:1 | |
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| 17. Ronde | 06.02.2022 | Sirens FC | - | Valletta FC | 2:1 | |
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| 18. Ronde | 12.02.2022 | Valletta FC | - | Hibernians FC | 1:4 | |
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| 19. Ronde | 20.02.2022 | St. Luċija FC | - | Valletta FC | 2:1 | ||||
| 20. Ronde | 26.02.2022 | Valletta FC | - | Sliema Wanderers | 1:0 | ||||
| 21. Ronde | 05.03.2022 | Mosta FC | - | Valletta FC | 2:2 |
Italië