| 2. Ronde | 20.08.2022 | Sassuolo Calcio | - | US Lecce | 1:0 | ||||
| 3. Ronde | 28.08.2022 | US Lecce | - | Empoli FC | 1:1 | ||||
| 4. Ronde | 31.08.2022 | SSC Napoli | - | US Lecce | 1:1 | ||||
| 5. Ronde | 05.09.2022 | Torino FC | - | US Lecce | 1:0 | ||||
| 6. Ronde | 11.09.2022 | US Lecce | - | AC Monza | 1:1 | ||||
| 7. Ronde | 16.09.2022 | US Salernitana 1919 | - | US Lecce | 1:2 | ||||
| 8. Ronde | 02.10.2022 | US Lecce | - | US Cremonese | 1:1 |  |
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| 9. Ronde | 09.10.2022 | AS Roma | - | US Lecce | 2:1 | ||||
| 10. Ronde | 17.10.2022 | US Lecce | - | ACF Fiorentina | 1:1 | ||||
| 11. Ronde | 23.10.2022 | Bologna FC | - | US Lecce | 2:0 | ||||
| 12. Ronde | 29.10.2022 | US Lecce | - | Juventus | 0:1 | ||||
| 15. Ronde | 12.11.2022 | Sampdoria | - | US Lecce | 0:2 | |
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| 16. Ronde | 04.01.2023 | US Lecce | - | Lazio | 2:1 | ||||
| 20. Ronde | 27.01.2023 | US Lecce | - | US Salernitana 1919 | 1:2 | ||||
| 21. Ronde | 04.02.2023 | US Cremonese | - | US Lecce | 0:2 | |
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| 22. Ronde | 11.02.2023 | US Lecce | - | AS Roma | 1:1 | ||||
| 23. Ronde | 19.02.2023 | Atalanta | - | US Lecce | 1:2 | ||||
| 24. Ronde | 25.02.2023 | US Lecce | - | Sassuolo Calcio | 0:1 | ||||
| 29. Ronde | 07.04.2023 | US Lecce | - | SSC Napoli | 1:2 | ||||
| 36. Ronde | 21.05.2023 | US Lecce | - | Spezia Calcio | 0:0 | ||||
| 37. Ronde | 28.05.2023 | AC Monza | - | US Lecce | 0:1 |
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