| 1. Ronde | 12.08.2021 | Balzan FC | - | Sliema Wanderers | 1:0 | ||||
| 2. Ronde | 20.08.2021 | Sliema Wanderers | - | Floriana FC | 0:0 | ||||
| 3. Ronde | 11.09.2021 | Gżira United | - | Sliema Wanderers | 1:1 | ||||
| 4. Ronde | 19.09.2021 | Sliema Wanderers | - | Gudja United | 2:3 |  |
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| 5. Ronde | 26.09.2021 | Sirens FC | - | Sliema Wanderers | 2:2 | ||||
| 6. Ronde | 17.10.2021 | Sliema Wanderers | - | Hibernians FC | 0:3 | ||||
| 7. Ronde | 24.10.2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 | |
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| 8. Ronde | 31.10.2021 | Sliema Wanderers | - | Mosta FC | 2:3 | ||||
| 9. Ronde | 20.11.2021 | Sliema Wanderers | - | Valletta FC | 0:3 Toeg. | ||||
| 13. Ronde | 19.12.2021 | Floriana FC | - | Sliema Wanderers | 2:0 |  |
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| 15. Ronde | 22.01.2022 | Gudja United | - | Sliema Wanderers | 1:0 | ||||
| 12. Ronde | 26.01.2022 | Sliema Wanderers | - | Balzan FC | 1:0 |  |
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| 16. Ronde | 29.01.2022 | Sliema Wanderers | - | Sirens FC | 1:0 | |
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| 17. Ronde | 05.02.2022 | Hibernians FC | - | Sliema Wanderers | 1:0 | ||||
| 18. Ronde | 13.02.2022 | Sliema Wanderers | - | St. Luċija FC | 1:1 | ||||
| 19. Ronde | 20.02.2022 | Mosta FC | - | Sliema Wanderers | 1:0 |
Malta