| 2. Ronde | 22.05.2021 | Cerro Largo | - | Cerrito | 3:1 | ||||
| 3. Ronde | 29.05.2021 | Liverpool | - | Cerro Largo | 3:0 | ||||
| 4. Ronde | 06.06.2021 | Cerro Largo | - | River Plate | 2:4 | ||||
| 5. Ronde | 13.06.2021 | Deportivo Maldonado | - | Cerro Largo | 2:1 | ||||
| 6. Ronde | 19.06.2021 | Progreso | - | Cerro Largo | 0:0 | ||||
| 7. Ronde | 22.06.2021 | Cerro Largo | - | Sud América | 2:1 | ||||
| 9. Ronde | 03.07.2021 | Cerro Largo | - | Fénix | 1:2 |  |
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| 10. Ronde | 11.07.2021 | Boston River | - | Cerro Largo | 1:0 | ||||
| 11. Ronde | 17.07.2021 | Cerro Largo | - | Montevideo Wanderers | 2:0 | ||||
| 13. Ronde | 06.08.2021 | Cerro Largo | - | Peñarol | 0:1 | ||||
| 14. Ronde | 15.08.2021 | Montevideo City Torque | - | Cerro Largo | 3:0 | ||||
| 15. Ronde | 22.08.2021 | Cerro Largo | - | Villa Española | 3:1 | |
Uruguay