| 2. Ronde | 14.02.2022 | Montevideo Wanderers | - | Cerro Largo | 1:0 | ||||
| 3. Ronde | 19.02.2022 | Cerro Largo | - | Plaza Colonia | 0:5 | ||||
| 6. Ronde | 22.03.2022 | Cerro Largo | - | Cerrito | 1:0 | ||||
| 8. Ronde | 09.04.2022 | Cerro Largo | - | Defensor Sporting | 0:0 | ||||
| 9. Ronde | 16.04.2022 | Albion | - | Cerro Largo | 2:1 | ||||
| 11. Ronde | 08.05.2022 | Danubio | - | Cerro Largo | 2:0 | ||||
| 13. Ronde | 21.05.2022 | Rentistas | - | Cerro Largo | 2:0 | ||||
| 14. Ronde | 28.05.2022 | Cerro Largo | - | Liverpool | 1:2 | ||||
| 15. Ronde | 04.06.2022 | Peñarol | - | Cerro Largo | 0:1 |
Uruguay