| 2. Ronde | 03.08.2021 | Atlético San Luis | - | Gallos Blancos | 1:1 | ||||
| 6. Ronde | 22.08.2021 | Atlético San Luis | - | Cruz Azul | 0:0 | ||||
| 7. Ronde | 28.08.2021 | Mazatlán FC | - | Atlético San Luis | 2:2 | ||||
| 10. Ronde | 26.09.2021 | Deportivo Toluca | - | Atlético San Luis | 1:2 | ||||
| 11. Ronde | 30.09.2021 | Atlético San Luis | - | UANL Tigres | 0:3 | ||||
| 15. Ronde | 25.10.2021 | Atlético San Luis | - | Atlas Guadalajara | 2:6 | ||||
| 16. Ronde | 01.11.2021 | Atlético San Luis | - | CF Monterrey | 1:1 |  |
|||
| 17. Ronde | 08.11.2021 | Santos Laguna | - | Atlético San Luis | 0:0 |
Brazilië
Uruguay