| 4. Ronde | 11.09.2021 | Southampton FC [U18] | - | Arsenal FC [U18] | 3:3 |  |
|||
| 5. Ronde | 25.09.2021 | Crystal Palace [U18] | - | Southampton FC [U18] | 1:0 | |
|||
| 7. Ronde | 23.10.2021 | West Bromwich Albion [U18] | - | Southampton FC [U18] | 1:5 | ||||
| 8. Ronde | 30.10.2021 | Southampton FC [U18] | - | Brighton & Hove Albion [U18] | 3:2 | ||||
| 9. Ronde | 06.11.2021 | Southampton FC [U18] | - | Aston Villa [U18] | 6:3 | ||||
| 10. Ronde | 20.11.2021 | Tottenham Hotspur [U18] | - | Southampton FC [U18] | 0:3 | ||||
| 11. Ronde | 04.12.2021 | Southampton FC [U18] | - | Fulham FC [U18] | 2:0 | ||||
| 15. Ronde | 22.01.2022 | Brighton & Hove Albion [U18] | - | Southampton FC [U18] | 3:4 | |
|||
| 16. Ronde | 04.02.2022 | Aston Villa [U18] | - | Southampton FC [U18] | 0:5 | ||||
| 17. Ronde | 19.02.2022 | Southampton FC [U18] | - | West Bromwich Albion [U18] | 2:1 | ||||
| 18. Ronde | 26.02.2022 | Fulham FC [U18] | - | Southampton FC [U18] | 2:3 |  |
|||
| 26. Ronde | 07.05.2022 | Southampton FC [U18] | - | Chelsea FC [U18] | 5:2 |
Frankrijk