| 1. Ronde | 18.01.2021 | Atlético Nacional | - | Santa Fe | 2:0 | ||||
| 3. Ronde | 30.01.2021 | Águilas Doradas | - | Santa Fe | 0:2 | ||||
| 4. Ronde | 04.02.2021 | Santa Fe | - | Patriotas FC | 1:0 | ||||
| 5. Ronde | 08.02.2021 | Jaguares de Córdoba | - | Santa Fe | 0:1 | ||||
| 6. Ronde | 14.02.2021 | Santa Fe | - | Atlético Bucaramanga | 2:0 | ||||
| 7. Ronde | 19.02.2021 | América de Cali | - | Santa Fe | 0:0 | ||||
| 9. Ronde | 25.02.2021 | Santa Fe | - | Boyacá Chicó | 2:0 | ||||
| 10. Ronde | 01.03.2021 | Deportivo Cali | - | Santa Fe | 1:1 | ||||
| 2. Ronde | 05.03.2021 | Santa Fe | - | Deportes Tolima | 3:2 | ||||
| 11. Ronde | 09.03.2021 | Santa Fe | - | Deportivo Pasto | 2:2 |  |
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| 13. Ronde | 20.03.2021 | Envigado FC | - | Santa Fe | 2:1 | ||||
| 14. Ronde | 24.03.2021 | Santa Fe | - | Once Caldas | 2:0 | ||||
| 15. Ronde | 28.03.2021 | Atlético Junior | - | Santa Fe | 1:1 | ||||
| 16. Ronde | 03.04.2021 | Santa Fe | - | Deportivo Pereira | 1:1 | ||||
| 17. Ronde | 07.04.2021 | Alianza Petrolera | - | Santa Fe | 0:3 | |
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| 18. Ronde | 12.04.2021 | Santa Fe | - | Millonarios | 1:2 | |
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| 19. Ronde | 18.04.2021 | La Equidad | - | Santa Fe | 1:2 |
Colombia