| 3. Ronde | 08.08.2021 | LD Alajuelense | - | CS Cartaginés | 2:3 | ||||
| 4. Ronde | 12.08.2021 | Santos de Guápiles | - | LD Alajuelense | 2:1 | ||||
| 5. Ronde | 15.08.2021 | LD Alajuelense | - | CS Herediano | 4:1 | ||||
| 6. Ronde | 17.08.2021 | AD Guanacasteca | - | LD Alajuelense | 1:2 | ||||
| 7. Ronde | 26.08.2021 | LD Alajuelense | - | Municipal Grecia | 1:0 | ||||
| 8. Ronde | 29.08.2021 | Deportivo Saprissa | - | LD Alajuelense | 4:2 | ||||
| 10. Ronde | 12.09.2021 | Guadalupe | - | LD Alajuelense | 2:4 | ||||
| 11. Ronde | 15.09.2021 | Municipal Pérez Zeledón | - | LD Alajuelense | 1:0 | ||||
| 12. Ronde | 18.09.2021 | LD Alajuelense | - | AD San Carlos | 2:2 | ||||
| 13. Ronde | 26.09.2021 | Sporting FC | - | LD Alajuelense | 0:3 |  |
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| 14. Ronde | 03.10.2021 | CS Cartaginés | - | LD Alajuelense | 1:0 | ||||
| 17. Ronde | 24.10.2021 | LD Alajuelense | - | AD Guanacasteca | 4:1 | ||||
| 18. Ronde | 27.10.2021 | Municipal Grecia | - | LD Alajuelense | 1:2 | ||||
| 19. Ronde | 31.10.2021 | LD Alajuelense | - | Deportivo Saprissa | 0:0 | ||||
| 20. Ronde | 21.11.2021 | Jicaral | - | LD Alajuelense | 0:3 | ||||
| 21. Ronde | 25.11.2021 | LD Alajuelense | - | Guadalupe | 1:0 |
Costa Rica