| 1. Ronde | 14.08.2021 | Floriana FC | - | St. Luċija FC | 2:2 | ||||
| 5. Ronde | 25.09.2021 | Hibernians FC | - | St. Luċija FC | 1:1 | ||||
| 8. Ronde | 30.10.2021 | Valletta FC | - | St. Luċija FC | 5:3 | ||||
| 11. Ronde | 05.12.2021 | St. Luċija FC | - | Balzan FC | 3:3 | ||||
| 13. Ronde | 18.12.2021 | Gżira United | - | St. Luċija FC | 2:2 | ||||
| 14. Ronde | 19.01.2022 | St. Luċija FC | - | Gudja United | 0:3 | ||||
| 15. Ronde | 23.01.2022 | Sirens FC | - | St. Luċija FC | 2:1 |
Malta