| 15. Ronde | 30.01.2022 | Nîmes Olympique [B-jun] | - | FC Istres [B-jun] | 1:1 | ||||
| 17. Ronde | 13.02.2022 | Rodez AF [B-jun] | - | FC Istres [B-jun] | 0:1 | ||||
| 18. Ronde | 06.03.2022 | FC Istres [B-jun] | - | Girondins Bordeaux [B-jun] | 3:2 | ||||
| 21. Ronde | 27.03.2022 | Toulouse FC [B-jun] | - | FC Istres [B-jun] | 5:0 | ||||
| 22. Ronde | 03.04.2022 | FC Istres [B-jun] | - | Pau FC [B-jun] | 5:2 | ||||
| 23. Ronde | 10.04.2022 | AS Béziers [B-jun] | - | FC Istres [B-jun] | 2:1 | ||||
| 24. Ronde | 17.04.2022 | Marignane Gignac [B-jun] | - | FC Istres [B-jun] | 1:1 | ||||
| 25. Ronde | 08.05.2022 | FC Istres [B-jun] | - | SA Mérignac [B-jun] | 2:0 | ||||
| 26. Ronde | 15.05.2022 | AS Muret [B-jun] | - | FC Istres [B-jun] | 3:0 |
Frankrijk