| 2. Ronde | 18.09.2021 | PAS Giannina | - | Panathinaikos | 1:0 | ||||
| 3. Ronde | 22.09.2021 | Aris Saloniki | - | Panathinaikos | 1:0 | ||||
| 6. Ronde | 16.10.2021 | Panathinaikos | - | Ionikos Nikea | 4:1 | ||||
| 8. Ronde | 31.10.2021 | Panathinaikos | - | OFI Heraklion | 0:0 | ||||
| 9. Ronde | 07.11.2021 | Panathinaikos | - | PAOK Saloniki | 1:3 |  |
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| 10. Ronde | 22.11.2021 | Lamia | - | Panathinaikos | 1:3 | ||||
| 11. Ronde | 28.11.2021 | Panathinaikos | - | Panetolikos | 2:0 | ||||
| 12. Ronde | 05.12.2021 | AEK Athene | - | Panathinaikos | 1:0 | ||||
| 13. Ronde | 11.12.2021 | Panathinaikos | - | Atromitos | 2:0 | |
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| 15. Ronde | 19.12.2021 | Panathinaikos | - | PAS Giannina | 2:0 | ||||
| 16. Ronde | 05.01.2022 | Panathinaikos | - | Aris Saloniki | 2:0 | |
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| 17. Ronde | 09.01.2022 | Volos NFC | - | Panathinaikos | 3:1 | ||||
| 18. Ronde | 16.01.2022 | Panathinaikos | - | Olympiakos | 0:0 | |
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| 19. Ronde | 22.01.2022 | Ionikos Nikea | - | Panathinaikos | 0:1 | ||||
| 21. Ronde | 02.02.2022 | OFI Heraklion | - | Panathinaikos | 3:2 |  |
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| 23. Ronde | 13.02.2022 | Panathinaikos | - | Lamia | 2:0 | ||||
| 14. Ronde | 16.02.2022 | Apollon Smyrnis | - | Panathinaikos | 0:3 | ||||
| 24. Ronde | 19.02.2022 | Panetolikos | - | Panathinaikos | 1:0 |
Argentinië
Paraguay