| 1. Ronde | 27.01.2023 | Libertad | - | Guaraní | 1:0 | ||||
| 2. Ronde | 04.02.2023 | Guaraní | - | Sportivo Ameliano | 2:2 | ||||
| 3. Ronde | 12.02.2023 | Cerro Porteño | - | Guaraní | 1:1 | ||||
| 4. Ronde | 17.02.2023 | Resistencia SC | - | Guaraní | 0:4 | ||||
| 5. Ronde | 25.02.2023 | Guaraní | - | Sportivo Luqueño | 3:1 | ||||
| 6. Ronde | 04.03.2023 | Club Nacional | - | Guaraní | 0:2 |  |
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| 7. Ronde | 14.03.2023 | Guaraní | - | Tacuary | 1:0 | ||||
| 8. Ronde | 20.03.2023 | Sportivo Trinidense | - | Guaraní | 1:1 | ||||
| 9. Ronde | 24.03.2023 | Guaraní | - | Guaireña FC | 1:1 | ||||
| 11. Ronde | 11.04.2023 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
| 12. Ronde | 14.04.2023 | Guaraní | - | Libertad | 0:0 | ||||
| 13. Ronde | 17.04.2023 | Sportivo Ameliano | - | Guaraní | 1:1 | ||||
| 14. Ronde | 25.04.2023 | Guaraní | - | Cerro Porteño | 0:3 | ||||
| 16. Ronde | 06.05.2023 | Sportivo Luqueño | - | Guaraní | 3:0 | ||||
| 17. Ronde | 14.05.2023 | Guaraní | - | Club Nacional | 2:2 | ||||
| 18. Ronde | 18.05.2023 | Tacuary | - | Guaraní | 1:3 | |
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| 19. Ronde | 22.05.2023 | Guaraní | - | Sportivo Trinidense | 0:2 | ||||
| 20. Ronde | 29.05.2023 | Guaireña FC | - | Guaraní | 2:2 | ||||
| 21. Ronde | 03.06.2023 | Guaraní | - | Club Olimpia | 1:2 | ||||
| 22. Ronde | 10.06.2023 | General Caballero DJLM | - | Guaraní | 0:0 |
Argentinië
Paraguay