| 2. Ronde | 18.07.2022 | Boca Juniors de Cali | - | Orsomarso SC | 2:1 |  |
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| 3. Ronde | 23.07.2022 | Orsomarso SC | - | Valledupar FC | 1:1 | |
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| 5. Ronde | 04.08.2022 | Real Cartagena | - | Orsomarso SC | 0:1 | ||||
| 7. Ronde | 14.08.2022 | Atlético FC | - | Orsomarso SC | 2:1 | |
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| 8. Ronde | 20.08.2022 | Orsomarso SC | - | Real Santander | 0:0 | |
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| 9. Ronde | 29.08.2022 | Deportes Quindío | - | Orsomarso SC | 2:0 | ||||
| 10. Ronde | 04.09.2022 | Cúcuta Deportivo | - | Orsomarso SC | 3:0 | ||||
| 11. Ronde | 07.09.2022 | Orsomarso SC | - | Llaneros FC | 2:2 | ||||
| 14. Ronde | 23.09.2022 | Bogotá FC | - | Orsomarso SC | 1:0 |
Colombia