| 1. Ronde | 10.07.2022 | H&H Export Sébaco | - | Juventus Managua | 0:0 | ||||
| 2. Ronde | 17.07.2022 | CD Walter Ferretti | - | H&H Export Sébaco | 1:2 |  |
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| 3. Ronde | 24.07.2022 | H&H Export Sébaco | - | Real Estelí FC | 0:0 | ||||
| 4. Ronde | 31.07.2022 | Matagalpa FC | - | H&H Export Sébaco | 1:2 | |
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| 5. Ronde | 07.08.2022 | H&H Export Sébaco | - | UNAN Managua | 5:0 | |
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| 6. Ronde | 11.08.2022 | Club Deportivo Ocotal | - | H&H Export Sébaco | 2:1 | |
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| 7. Ronde | 14.08.2022 | H&H Export Sébaco | - | Managua FC | 2:1 | |
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| 9. Ronde | 28.08.2022 | ART Municipal Jalapa | - | H&H Export Sébaco | 1:0 | ||||
| 10. Ronde | 04.09.2022 | Juventus Managua | - | H&H Export Sébaco | 1:1 | ||||
| 11. Ronde | 11.09.2022 | H&H Export Sébaco | - | CD Walter Ferretti | 1:1 | |
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| 12. Ronde | 03.10.2022 | Real Estelí FC | - | H&H Export Sébaco | 3:1 | |
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| 13. Ronde | 23.10.2022 | H&H Export Sébaco | - | Matagalpa FC | 2:1 | |
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| 14. Ronde | 27.10.2022 | UNAN Managua | - | H&H Export Sébaco | 0:0 | |
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| 15. Ronde | 30.10.2022 | H&H Export Sébaco | - | Club Deportivo Ocotal | 2:0 | |
Nicaragua