| 1. Ronde | 26.07.2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 1:1 | ||||
| 2. Ronde | 30.07.2021 | Mazatlán FC [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 3. Ronde | 06.08.2021 | Mazatlán FC [U20] | - | CF Monterrey [U20] | 1:4 | ||||
| 5. Ronde | 17.08.2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 7. Ronde | 27.08.2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 3:1 |  |
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| 8. Ronde | 11.09.2021 | CF América [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 9. Ronde | 18.09.2021 | Mazatlán FC [U20] | - | Pumas UNAM [U20] | 2:1 |  |
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| 10. Ronde | 25.09.2021 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 3:5 | |
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| 11. Ronde | 28.09.2021 | Mazatlán FC [U20] | - | FC Juárez [U20] | 2:2 | ||||
| 12. Ronde | 02.10.2021 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 4:2 | ||||
| 13. Ronde | 15.10.2021 | Mazatlán FC [U20] | - | Atlas Guadalajara [U20] | 3:1 | |
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| 14. Ronde | 19.10.2021 | Puebla FC [U20] | - | Mazatlán FC [U20] | 2:1 | ||||
| 15. Ronde | 22.10.2021 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 4:0 | ||||
| 16. Ronde | 29.10.2021 | Club Necaxa [U20] | - | Mazatlán FC [U20] | 1:1 | ||||
| 17. Ronde | 05.11.2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 1:0 |
Mexico