| 2. Ronde | 09.07.2022 | Deportivo Coopsol | - | Santos FC | 0:1 | ||||
| 4. Ronde | 23.07.2022 | Juan Aurich | - | Santos FC | 0:1 | ||||
| 5. Ronde | 31.07.2022 | Santos FC | - | Alianza Universidad | 2:2 | ||||
| 7. Ronde | 14.08.2022 | Santos FC | - | Unión Comercio | 1:0 |  |
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| 8. Ronde | 21.08.2022 | Cusco FC | - | Santos FC | 4:1 | ||||
| 9. Ronde | 28.08.2022 | Santos FC | - | Alfonso Ugarte | 1:0 | ||||
| 10. Ronde | 04.09.2022 | Chavelines Juniors | - | Santos FC | 1:2 | ||||
| 12. Ronde | 18.09.2022 | Llacuabamba | - | Santos FC | 3:0 | ||||
| 13. Ronde | 25.09.2022 | Santos FC | - | Los Chankas | 5:0 |  |
Colombia