| 7. Ronde | 06.02.2021 | Guadalupe | - | Sporting FC | 0:0 | ||||
| 8. Ronde | 16.02.2021 | Municipal Pérez Zeledón | - | Guadalupe | 1:3 |  |
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| 9. Ronde | 21.02.2021 | Guadalupe | - | Municipal Grecia | 1:1 | ||||
| 10. Ronde | 27.02.2021 | Jicaral | - | Guadalupe | 3:2 | ||||
| 11. Ronde | 04.03.2021 | Guadalupe | - | LD Alajuelense | 1:3 | ||||
| 12. Ronde | 06.03.2021 | Limón FC | - | Guadalupe | 1:7 | ||||
| 13. Ronde | 14.03.2021 | Guadalupe | - | CS Cartaginés | 0:3 | |
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| 14. Ronde | 21.03.2021 | Guadalupe | - | AD San Carlos | 1:2 | |
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| 15. Ronde | 01.04.2021 | Deportivo Saprissa | - | Guadalupe | 1:1 | ||||
| 16. Ronde | 04.04.2021 | Guadalupe | - | Santos de Guápiles | 2:4 | ||||
| 17. Ronde | 11.04.2021 | Guadalupe | - | CS Herediano | 2:2 | ||||
| 18. Ronde | 18.04.2021 | Sporting FC | - | Guadalupe | 0:3 | ||||
| 19. Ronde | 22.04.2021 | Guadalupe | - | Municipal Pérez Zeledón | 0:1 | ||||
| 20. Ronde | 25.04.2021 | Municipal Grecia | - | Guadalupe | 0:0 | ||||
| 21. Ronde | 02.05.2021 | Guadalupe | - | Jicaral | 0:0 | ||||
| 22. Ronde | 13.05.2021 | LD Alajuelense | - | Guadalupe | 0:0 |
Costa Rica