| 1. Ronde | 13.01.2022 | Guadalupe | - | CS Cartaginés | 3:2 | ||||
| 2. Ronde | 16.01.2022 | LD Alajuelense | - | Guadalupe | 1:0 | ||||
| 3. Ronde | 21.01.2022 | Sporting FC | - | Guadalupe | 2:2 |  |
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| 4. Ronde | 04.02.2022 | Guadalupe | - | AD San Carlos | 3:1 | ||||
| 5. Ronde | 10.02.2022 | Guadalupe | - | Municipal Grecia | 3:1 | ||||
| 6. Ronde | 12.02.2022 | Jicaral | - | Guadalupe | 2:0 | ||||
| 7. Ronde | 19.02.2022 | Guadalupe | - | Santos de Guápiles | 4:1 | ||||
| 8. Ronde | 27.02.2022 | Deportivo Saprissa | - | Guadalupe | 2:1 | ||||
| 9. Ronde | 03.03.2022 | Municipal Pérez Zeledón | - | Guadalupe | 0:1 | ||||
| 10. Ronde | 06.03.2022 | Guadalupe | - | CS Herediano | 1:1 | ||||
| 11. Ronde | 01.04.2022 | AD Guanacasteca | - | Guadalupe | 1:2 | ||||
| 12. Ronde | 08.04.2022 | CS Cartaginés | - | Guadalupe | 4:1 | ||||
| 13. Ronde | 11.04.2022 | Guadalupe | - | LD Alajuelense | 0:2 | ||||
| 17. Ronde | 28.04.2022 | Guadalupe | - | Jicaral | 1:0 | ||||
| 18. Ronde | 01.05.2022 | Santos de Guápiles | - | Guadalupe | 6:0 | ||||
| 19. Ronde | 05.05.2022 | Guadalupe | - | Deportivo Saprissa | 1:2 | |
Costa Rica