| 8. Ronde | 14.02.2021 | Sporting FC | - | CS Cartaginés | 3:1 |  |
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| 9. Ronde | 21.02.2021 | CS Cartaginés | - | LD Alajuelense | 1:1 | ||||
| 10. Ronde | 27.02.2021 | Municipal Grecia | - | CS Cartaginés | 1:2 | ||||
| 11. Ronde | 03.03.2021 | CS Cartaginés | - | Jicaral | 1:1 | ||||
| 12. Ronde | 09.03.2021 | Santos de Guápiles | - | CS Cartaginés | 1:0 | |
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| 13. Ronde | 14.03.2021 | Guadalupe | - | CS Cartaginés | 0:3 | ||||
| 14. Ronde | 20.03.2021 | CS Cartaginés | - | Municipal Pérez Zeledón | 0:0 | ||||
| 15. Ronde | 31.03.2021 | Limón FC | - | CS Cartaginés | 1:1 | ||||
| 19. Ronde | 21.04.2021 | CS Cartaginés | - | Sporting FC | 0:1 | |
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| 20. Ronde | 25.04.2021 | LD Alajuelense | - | CS Cartaginés | 4:1 | ||||
| 21. Ronde | 01.05.2021 | CS Cartaginés | - | Municipal Grecia | 2:0 | ||||
| 22. Ronde | 13.05.2021 | Jicaral | - | CS Cartaginés | 1:0 |
Costa Rica