| 4. Ronde | 05.06.2021 | Plaza Colonia | - | Nacional | 1:2 | ||||
| 6. Ronde | 19.06.2021 | Boston River | - | Nacional | 1:1 | ||||
| 7. Ronde | 24.06.2021 | Nacional | - | Montevideo Wanderers | 3:0 | ||||
| 8. Ronde | 27.06.2021 | Rentistas | - | Nacional | 1:1 | ||||
| 9. Ronde | 04.07.2021 | Nacional | - | Peñarol | 2:0 |  |
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| 11. Ronde | 25.07.2021 | Nacional | - | Villa Española | 3:0 | ||||
| 12. Ronde | 02.08.2021 | Nacional | - | Deportivo Maldonado | 2:0 | ||||
| 13. Ronde | 08.08.2021 | Cerrito | - | Nacional | 2:0 |
Uruguay