| 1. Ronde | 01.08.2021 | Alianza | - | Municipal Limeño | 4:1 | ||||
| 2. Ronde | 08.08.2021 | Platense Zacatecoluca | - | Alianza | 2:2 | ||||
| 3. Ronde | 11.08.2021 | AD Chalatenango | - | Alianza | 2:1 | ||||
| 4. Ronde | 15.08.2021 | Alianza | - | Luis Ángel Firpo | 2:2 | ||||
| 6. Ronde | 26.08.2021 | Alianza | - | FAS | 1:0 | ||||
| 9. Ronde | 16.09.2021 | Santa Tecla FC | - | Alianza | 0:4 | ||||
| 10. Ronde | 19.09.2021 | Alianza | - | CD Águila | 2:1 | ||||
| 12. Ronde | 02.10.2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 13. Ronde | 17.10.2021 | Alianza | - | Platense Zacatecoluca | 4:0 |  |
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| 14. Ronde | 21.10.2021 | Alianza | - | AD Chalatenango | 1:0 | |
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| 15. Ronde | 24.10.2021 | Luis Ángel Firpo | - | Alianza | 2:1 | ||||
| 16. Ronde | 30.10.2021 | Once Municipal | - | Alianza | 2:3 | ||||
| 17. Ronde | 02.11.2021 | FAS | - | Alianza | 0:1 | ||||
| 22. Ronde | 27.11.2021 | Alianza | - | Jocoro FC | 2:0 |
El Salvador