| 1. Ronde | 17.07.2021 | CS Universitatea Craiova | - | Argeș Pitești | 1:0 | ||||
| 3. Ronde | 01.08.2021 | CS Universitatea Craiova | - | FC Botoşani | 1:2 |  |
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| 4. Ronde | 09.08.2021 | CS Universitatea Craiova | - | FC Voluntari | 3:0 | ||||
| 6. Ronde | 21.08.2021 | CS Universitatea Craiova | - | Gaz Metan Mediaş | 1:0 | ||||
| 8. Ronde | 13.09.2021 | CS Universitatea Craiova | - | Sepsi OSK | 1:1 | ||||
| 10. Ronde | 27.09.2021 | CS Universitatea Craiova | - | Dinamo Boekarest | 5:0 | |
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| 12. Ronde | 18.10.2021 | CS Universitatea Craiova | - | Academica Clinceni | 5:0 | ||||
| 14. Ronde | 30.10.2021 | CS Universitatea Craiova | - | CS Mioveni | 5:2 | ||||
| 16. Ronde | 21.11.2021 | Argeș Pitești | - | CS Universitatea Craiova | 3:2 | ||||
| 17. Ronde | 28.11.2021 | CS Universitatea Craiova | - | FCSB | 2:3 | |
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| 18. Ronde | 06.12.2021 | FC Botoşani | - | CS Universitatea Craiova | 2:2 | |
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| 21. Ronde | 18.12.2021 | Gaz Metan Mediaş | - | CS Universitatea Craiova | 1:1 | ||||
| 22. Ronde | 22.01.2022 | CS Universitatea Craiova | - | Rapid Bucureşti | 1:0 | ||||
| 23. Ronde | 28.01.2022 | Sepsi OSK | - | CS Universitatea Craiova | 3:1 |
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