| 1. Ronde | 01.08.2021 | Once Municipal | - | CD Águila | 2:2 | ||||
| 2. Ronde | 08.08.2021 | CD Águila | - | FAS | 1:1 | ||||
| 3. Ronde | 12.08.2021 | Isidro Metapán | - | CD Águila | 2:2 | ||||
| 7. Ronde | 29.08.2021 | CD Águila | - | Jocoro FC | 2:2 | ||||
| 10. Ronde | 19.09.2021 | Alianza | - | CD Águila | 2:1 | ||||
| 11. Ronde | 26.09.2021 | CD Águila | - | Luis Ángel Firpo | 1:1 | ||||
| 12. Ronde | 03.10.2021 | CD Águila | - | Once Municipal | 1:2 |  |
|||
| 13. Ronde | 18.10.2021 | FAS | - | CD Águila | 0:1 | ||||
| 14. Ronde | 21.10.2021 | CD Águila | - | Isidro Metapán | 4:0 | ||||
| 15. Ronde | 24.10.2021 | Atlético Marte | - | CD Águila | 1:2 | ||||
| 16. Ronde | 31.10.2021 | CD Águila | - | Santa Tecla FC | 2:0 | ||||
| 17. Ronde | 03.11.2021 | AD Chalatenango | - | CD Águila | 1:1 | ||||
| 18. Ronde | 06.11.2021 | Jocoro FC | - | CD Águila | 2:2 | ||||
| 19. Ronde | 14.11.2021 | CD Águila | - | Municipal Limeño | 2:1 | ||||
| 20. Ronde | 17.11.2021 | Platense Zacatecoluca | - | CD Águila | 3:2 | |
|||
| 21. Ronde | 21.11.2021 | CD Águila | - | Alianza | 0:1 |
El Salvador