| 4. Ronde | 06.08.2021 | FC Botoşani | - | UTA Arad | 2:1 | ||||
| 5. Ronde | 16.08.2021 | Gaz Metan Mediaş | - | FC Botoşani | 0:1 |  |
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| 6. Ronde | 22.08.2021 | FC Botoşani | - | Rapid Bucureşti | 0:2 | ||||
| 7. Ronde | 29.08.2021 | Sepsi OSK | - | FC Botoşani | 1:1 | ||||
| 9. Ronde | 19.09.2021 | Dinamo Boekarest | - | FC Botoşani | 1:2 | ||||
| 10. Ronde | 26.09.2021 | FC Botoşani | - | FC Universitatea Craiova | 1:1 | ||||
| 12. Ronde | 18.10.2021 | FC Botoşani | - | Chindia Târgoviște | 0:0 | ||||
| 13. Ronde | 23.10.2021 | CS Mioveni | - | FC Botoşani | 1:1 |  |
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| 14. Ronde | 29.10.2021 | FC Botoşani | - | Farul Constanța | 0:2 | |
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| 15. Ronde | 05.11.2021 | Argeș Pitești | - | FC Botoşani | 0:1 | ||||
| 16. Ronde | 21.11.2021 | FCSB | - | FC Botoşani | 3:1 | ||||
| 20. Ronde | 15.12.2021 | FC Botoşani | - | Gaz Metan Mediaş | 2:1 | ||||
| 21. Ronde | 18.12.2021 | Rapid Bucureşti | - | FC Botoşani | 1:1 | ||||
| 24. Ronde | 07.02.2022 | FC Botoşani | - | Dinamo Boekarest | 4:0 | ||||
| 27. Ronde | 20.02.2022 | Chindia Târgoviște | - | FC Botoşani | 1:1 | |
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| 28. Ronde | 27.02.2022 | FC Botoşani | - | CS Mioveni | 0:0 | ||||
| 29. Ronde | 03.03.2022 | Farul Constanța | - | FC Botoşani | 2:0 | ||||
| 30. Ronde | 07.03.2022 | FC Botoşani | - | Argeș Pitești | 1:2 |
Brazilië