| 1. Ronde | 15.08.2021 | Liverpool FC U23 | - | Manchester City U23 | 0:0 | ||||
| 4. Ronde | 11.09.2021 | Tottenham Hotspur U23 | - | Liverpool FC U23 | 2:1 | ||||
| 5. Ronde | 19.09.2021 | Liverpool FC U23 | - | Leeds United U23 | 0:4 | ||||
| 6. Ronde | 24.09.2021 | Chelsea FC U23 | - | Liverpool FC U23 | 4:3 |  |
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| 7. Ronde | 02.10.2021 | Manchester United U23 | - | Liverpool FC U23 | 3:0 | ||||
| 8. Ronde | 16.10.2021 | Liverpool FC U23 | - | Arsenal FC U23 | 3:0 | |
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| 11. Ronde | 06.11.2021 | West Ham United U23 | - | Liverpool FC U23 | 3:0 | ||||
| 12. Ronde | 20.11.2021 | Liverpool FC U23 | - | Crystal Palace U23 | 0:3 | ||||
| 14. Ronde | 03.12.2021 | Brighton & Hove Albion U23 | - | Liverpool FC U23 | 3:0 | ||||
| 17. Ronde | 15.01.2022 | Liverpool FC U23 | - | Everton FC U23 | 1:1 | ||||
| 22. Ronde | 12.03.2022 | Liverpool FC U23 | - | Tottenham Hotspur U23 | 7:1 | ||||
| 15. Ronde | 17.04.2022 | Liverpool FC U23 | - | West Ham United U23 | 3:0 |
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