| 2. Ronde | 20.09.2021 | Deportivo Maldonado | - | Montevideo Wanderers | 1:3 |  |
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| 3. Ronde | 26.09.2021 | Montevideo Wanderers | - | Rentistas | 2:1 | ||||
| 4. Ronde | 04.10.2021 | Peñarol | - | Montevideo Wanderers | 3:0 |  |
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| 5. Ronde | 09.10.2021 | Montevideo Wanderers | - | Montevideo City Torque | 0:1 | ||||
| 6. Ronde | 17.10.2021 | Villa Española | - | Montevideo Wanderers | 2:2 | ||||
| 9. Ronde | 30.10.2021 | Montevideo Wanderers | - | Liverpool | 1:0 | ||||
| 11. Ronde | 08.11.2021 | Montevideo Wanderers | - | Cerro Largo | 1:2 | ||||
| 12. Ronde | 15.11.2021 | Progreso | - | Montevideo Wanderers | 3:1 | ||||
| 14. Ronde | 26.11.2021 | Plaza Colonia | - | Montevideo Wanderers | 0:1 |
Uruguay
Italië