| 1. Ronde | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 |  |
|||
| 2. Ronde | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 | |
|||
| 3. Ronde | 16.06.2021 | Albion | - | Defensor Sporting | 2:2 | ||||
| 4. Ronde | 26.06.2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 5. Ronde | 01.07.2021 | Atenas | - | Defensor Sporting | 2:0 | |
|||
| 13. Ronde | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 |  |
|
||
| 14. Ronde | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | |
|||
| 16. Ronde | 12.10.2021 | Defensor Sporting | - | Atenas | 1:1 | |
|||
| 17. Ronde | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | ||||
| 19. Ronde | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 |
Uruguay