| 1. Ronde | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 |  |
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| 2. Ronde | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 3. Ronde | 16.06.2021 | Albion | - | Defensor Sporting | 2:2 | ||||
| 4. Ronde | 26.06.2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 5. Ronde | 01.07.2021 | Atenas | - | Defensor Sporting | 2:0 | |
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| 6. Ronde | 09.07.2021 | Defensor Sporting | - | Racing | 1:4 | ||||
| 7. Ronde | 15.07.2021 | Villa Teresa | - | Defensor Sporting | 0:2 | ||||
| 8. Ronde | 22.07.2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | ||||
| 9. Ronde | 28.07.2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | ||||
| 10. Ronde | 05.08.2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | |
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| 11. Ronde | 14.08.2021 | Danubio | - | Defensor Sporting | 0:1 |  |
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| 13. Ronde | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 14. Ronde | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 15. Ronde | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 | |
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| 18. Ronde | 29.10.2021 | Defensor Sporting | - | Villa Teresa | 1:2 |
Uruguay