| 1. Ronde | 19.09.2021 | SC Faetano | - | SS Pennarossa | 0:1 | ||||
| 2. Ronde | 25.09.2021 | SS Pennarossa | - | SS San Giovanni | 1:0 | ||||
| 3. Ronde | 03.10.2021 | SP Cailungo | - | SS Pennarossa | 1:2 |  |
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| 4. Ronde | 16.10.2021 | SS Pennarossa | - | AC Juvenes/Dogana | 0:0 | ||||
| 13. Ronde | 19.12.2021 | AC Libertas | - | SS Pennarossa | 1:1 | |
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| 18. Ronde | 30.01.2022 | SS Pennarossa | - | SP Cailungo | 1:1 | ||||
| 19. Ronde | 06.02.2022 | AC Juvenes/Dogana | - | SS Pennarossa | 0:2 | |
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| 22. Ronde | 19.02.2022 | SS Pennarossa | - | FC Fiorentino | 2:1 | |
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| 14. Ronde | 22.02.2022 | SS Pennarossa | - | SP La Fiorita | 0:0 | ||||
| 23. Ronde | 26.02.2022 | SS Pennarossa | - | FC Domagnano | 1:0 | ||||
| 25. Ronde | 09.03.2022 | SS Murata | - | SS Pennarossa | 0:0 | ||||
| 26. Ronde | 13.03.2022 | SS Pennarossa | - | SP Tre Penne | 1:1 | ||||
| 15. Ronde | 16.03.2022 | SS Cosmos | - | SS Pennarossa | 0:3 | |
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| 27. Ronde | 20.03.2022 | SS Virtus | - | SS Pennarossa | 0:2 | |
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| 16. Ronde | 02.04.2022 | SS Pennarossa | - | SC Faetano | 0:2 | ||||
| 17. Ronde | 06.04.2022 | SS San Giovanni | - | SS Pennarossa | 1:1 | |
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| 29. Ronde | 14.04.2022 | SP La Fiorita | - | SS Pennarossa | 1:0 | ||||
| 30. Ronde | 21.04.2022 | SS Pennarossa | - | SS Cosmos | 2:1 |
San Marino