| 1. Ronde | 19.02.2022 | Mushuc Runa | - | Universidad Catolica | 1:2 | ||||
| 2. Ronde | 27.02.2022 | 9 de Octubre | - | Mushuc Runa | 2:0 | ||||
| 3. Ronde | 05.03.2022 | Técnico Universitario | - | Mushuc Runa | 1:3 | ||||
| 4. Ronde | 12.03.2022 | Mushuc Runa | - | Cumbayá | 4:2 | ||||
| 5. Ronde | 20.03.2022 | Mushuc Runa | - | Barcelona | 1:1 |  |
|||
| 6. Ronde | 03.04.2022 | Orense SC | - | Mushuc Runa | 0:0 | ||||
| 7. Ronde | 09.04.2022 | Mushuc Runa | - | Delfín SC | 1:2 | ||||
| 8. Ronde | 16.04.2022 | Gualaceo SC | - | Mushuc Runa | 3:2 |  |
|
||
| 9. Ronde | 21.04.2022 | Mushuc Runa | - | Macará | 0:0 | ||||
| 10. Ronde | 24.04.2022 | LDU Quito | - | Mushuc Runa | 3:2 | ||||
| 11. Ronde | 30.04.2022 | Mushuc Runa | - | Guayaquil City | 2:0 | ||||
| 12. Ronde | 08.05.2022 | Emelec | - | Mushuc Runa | 4:0 | ||||
| 13. Ronde | 14.05.2022 | Mushuc Runa | - | Aucas | 1:1 | ||||
| 14. Ronde | 23.05.2022 | Independiente del Valle | - | Mushuc Runa | 0:1 | ||||
| 15. Ronde | 28.05.2022 | Mushuc Runa | - | Deportivo Cuenca | 1:0 | |
Uruguay