| 1. Ronde | 25.07.2021 | Leones FC | - | Orsomarso SC | 1:0 | ||||
| 4. Ronde | 16.08.2021 | Orsomarso SC | - | Barranquilla FC | 0:0 | ||||
| 8. Ronde | 11.09.2021 | Valledupar FC | - | Orsomarso SC | 1:2 | ||||
| 9. Ronde | 21.09.2021 | Orsomarso SC | - | Boyacá Chicó | 2:1 | ||||
| 10. Ronde | 25.09.2021 | Fortaleza FC | - | Orsomarso SC | 4:0 | ||||
| 11. Ronde | 02.10.2021 | Orsomarso SC | - | Real Santander | 3:1 | ||||
| 12. Ronde | 11.10.2021 | Cortuluá | - | Orsomarso SC | 1:1 | ||||
| 13. Ronde | 18.10.2021 | Orsomarso SC | - | Unión Magdalena | 1:2 | ||||
| 14. Ronde | 23.10.2021 | Boca Juniors de Cali | - | Orsomarso SC | 2:1 | ||||
| 15. Ronde | 30.10.2021 | Orsomarso SC | - | Real Cartagena | 1:1 |  |
Colombia