| 1. Ronde | 24.01.2022 | Llaneros FC | - | Orsomarso SC | 0:1 | ||||
| 2. Ronde | 31.01.2022 | Orsomarso SC | - | Deportes Quindío | 1:1 | ||||
| 3. Ronde | 06.02.2022 | Boyacá Chicó | - | Orsomarso SC | 2:1 | ||||
| 4. Ronde | 14.02.2022 | Orsomarso SC | - | Boca Juniors de Cali | 2:0 | ||||
| 5. Ronde | 20.02.2022 | Valledupar FC | - | Orsomarso SC | 2:0 | ||||
| 6. Ronde | 26.02.2022 | Orsomarso SC | - | Tigres FC | 0:2 | ||||
| 7. Ronde | 07.03.2022 | Fortaleza FC | - | Orsomarso SC | 6:2 | ||||
| 8. Ronde | 10.03.2022 | Orsomarso SC | - | Barranquilla FC | 2:1 |  |
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| 9. Ronde | 20.03.2022 | Atlético Huila | - | Orsomarso SC | 0:1 | |
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| 10. Ronde | 28.03.2022 | Orsomarso SC | - | Real Cartagena | 1:2 | ||||
| 11. Ronde | 03.04.2022 | Real Santander | - | Orsomarso SC | 0:0 | ||||
| 12. Ronde | 10.04.2022 | Orsomarso SC | - | Atlético FC | 1:0 | |
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| 13. Ronde | 18.04.2022 | Leones FC | - | Orsomarso SC | 3:1 | ||||
| 14. Ronde | 23.04.2022 | Orsomarso SC | - | Bogotá FC | 1:1 |
Colombia