| 1. Ronde | 16.01.2021 | Danubio | - | Cerro Largo | 0:3 | ||||
| 5. Ronde | 07.02.2021 | Danubio | - | Montevideo City Torque | 0:4 | ||||
| 8. Ronde | 18.02.2021 | Fénix | - | Danubio | 1:1 |  |
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| 9. Ronde | 22.02.2021 | Danubio | - | CA Cerro | 2:1 | |
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| 10. Ronde | 28.02.2021 | Defensor Sporting | - | Danubio | 1:1 | |
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| 12. Ronde | 13.03.2021 | Danubio | - | Nacional | 2:1 | ||||
| 13. Ronde | 19.03.2021 | Boston River | - | Danubio | 1:5 | ||||
| 14. Ronde | 23.03.2021 | Danubio | - | Deportivo Maldonado | 2:2 | ||||
| 15. Ronde | 29.03.2021 | Rentistas | - | Danubio | 1:0 |
Uruguay