| 6. Ronde | 09.07.2021 | Defensor Sporting | - | Racing | 1:4 | ||||
| 7. Ronde | 15.07.2021 | Villa Teresa | - | Defensor Sporting | 0:2 | ||||
| 8. Ronde | 22.07.2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | ||||
| 10. Ronde | 05.08.2021 | Defensor Sporting | - | Rampla Juniors | 1:0 |  |
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| 15. Ronde | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 | ||||
| 16. Ronde | 12.10.2021 | Defensor Sporting | - | Atenas | 1:1 | ||||
| 17. Ronde | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | |
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| 18. Ronde | 29.10.2021 | Defensor Sporting | - | Villa Teresa | 1:2 | ||||
| 19. Ronde | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 |
Uruguay