| 1. Ronde | 11.09.2021 | KF Tiranë | - | KF Skënderbeu | 4:2 | ||||
| 2. Ronde | 18.09.2021 | KF Skënderbeu | - | FK Partizani | 1:1 | ||||
| 3. Ronde | 27.09.2021 | Egnatia Rrogozhine | - | KF Skënderbeu | 1:1 | ||||
| 4. Ronde | 02.10.2021 | KF Skënderbeu | - | FK Vllaznia | 0:0 | ||||
| 5. Ronde | 16.10.2021 | KS Kastrioti | - | KF Skënderbeu | 2:0 |  |
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| 9. Ronde | 21.11.2021 | KF Teuta Durrës | - | KF Skënderbeu | 2:2 |  |
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| 11. Ronde | 04.12.2021 | FK Partizani | - | KF Skënderbeu | 2:1 | ||||
| 12. Ronde | 08.12.2021 | KF Skënderbeu | - | Egnatia Rrogozhine | 2:0 | ||||
| 13. Ronde | 12.12.2021 | FK Vllaznia | - | KF Skënderbeu | 2:0 | ||||
| 14. Ronde | 18.12.2021 | KF Skënderbeu | - | KS Kastrioti | 2:1 | |
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| 16. Ronde | 15.01.2022 | KF Skënderbeu | - | KF Laçi | 0:0 | ||||
| 17. Ronde | 23.01.2022 | FK Kukësi | - | KF Skënderbeu | 1:0 | ||||
| 21. Ronde | 19.02.2022 | Egnatia Rrogozhine | - | KF Skënderbeu | 2:0 | ||||
| 22. Ronde | 25.02.2022 | KF Skënderbeu | - | FK Vllaznia | 2:2 | ||||
| 23. Ronde | 03.03.2022 | KS Kastrioti | - | KF Skënderbeu | 1:0 |  |
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| 29. Ronde | 17.04.2022 | FK Partizani | - | KF Skënderbeu | 0:0 | ||||
| 32. Ronde | 04.05.2022 | KF Skënderbeu | - | KS Kastrioti | 2:0 |
Noord-Macedonië