| 1. Ronde | 01.08.2021 | AD Chalatenango | - | Platense Zacatecoluca | 2:2 | ||||
| 5. Ronde | 22.08.2021 | FAS | - | Platense Zacatecoluca | 0:1 | ||||
| 8. Ronde | 12.09.2021 | Platense Zacatecoluca | - | Santa Tecla FC | 1:0 | ||||
| 9. Ronde | 16.09.2021 | CD Águila | - | Platense Zacatecoluca | 1:0 | ||||
| 10. Ronde | 19.09.2021 | Platense Zacatecoluca | - | Jocoro FC | 1:1 | ||||
| 12. Ronde | 02.10.2021 | Platense Zacatecoluca | - | AD Chalatenango | 2:1 |  |
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| 14. Ronde | 09.10.2021 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:3 | ||||
| 13. Ronde | 17.10.2021 | Alianza | - | Platense Zacatecoluca | 4:0 | ||||
| 15. Ronde | 24.10.2021 | Once Municipal | - | Platense Zacatecoluca | 1:1 | |
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| 16. Ronde | 30.10.2021 | Platense Zacatecoluca | - | FAS | 0:0 | ||||
| 17. Ronde | 03.11.2021 | Isidro Metapán | - | Platense Zacatecoluca | 1:0 | ||||
| 18. Ronde | 07.11.2021 | Atlético Marte | - | Platense Zacatecoluca | 0:0 | ||||
| 20. Ronde | 17.11.2021 | Platense Zacatecoluca | - | CD Águila | 3:2 |
El Salvador