| 1. Ronde | 23.01.2022 | Valledupar FC | - | Real Santander | 1:0 | ||||
| 9. Ronde | 20.03.2022 | Valledupar FC | - | Boca Juniors de Cali | 2:1 |  |
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| 11. Ronde | 03.04.2022 | Tigres FC | - | Valledupar FC | 3:2 | ||||
| 12. Ronde | 10.04.2022 | Valledupar FC | - | Fortaleza FC | 1:1 | ||||
| 13. Ronde | 16.04.2022 | Barranquilla FC | - | Valledupar FC | 1:1 | ||||
| 14. Ronde | 24.04.2022 | Valledupar FC | - | Atlético Huila | 1:0 | ||||
| 15. Ronde | 04.05.2022 | Real Cartagena | - | Valledupar FC | 1:2 | |
Colombia