| 2. Ronde | 12.08.2021 | Olimpia | - | Real España | 1:1 | ||||
| 3. Ronde | 16.08.2021 | Platense | - | Real España | 0:2 |  |
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| 9. Ronde | 16.09.2021 | Honduras Progreso | - | Real España | 1:1 | ||||
| 13. Ronde | 10.10.2021 | Victoria | - | Real España | 0:2 | ||||
| 14. Ronde | 17.10.2021 | Real España | - | Platense | 2:1 | ||||
| 1. Ronde | 21.10.2021 | Real España | - | Victoria | 1:1 | ||||
| 16. Ronde | 28.10.2021 | Real España | - | Honduras Progreso | 4:1 |  |
Honduras