| 1. Ronde | 01.08.2021 | Real Estelí FC | - | H&H Export Sébaco | 4:0 | ||||
| 2. Ronde | 10.08.2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 |  |
|||
| 3. Ronde | 15.08.2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 4. Ronde | 22.08.2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 5. Ronde | 29.08.2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 | ||||
| 6. Ronde | 03.09.2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
| 7. Ronde | 12.09.2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 | ||||
| 8. Ronde | 19.09.2021 | Diriangén FC | - | H&H Export Sébaco | 1:0 | ||||
| 11. Ronde | 10.10.2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 12. Ronde | 16.10.2021 | Club Deportivo Ocotal | - | H&H Export Sébaco | 1:1 | ||||
| 13. Ronde | 21.10.2021 | Managua FC | - | H&H Export Sébaco | 1:2 | ||||
| 14. Ronde | 23.10.2021 | H&H Export Sébaco | - | Juventus Managua | 3:3 | ||||
| 15. Ronde | 31.10.2021 | CD Walter Ferretti | - | H&H Export Sébaco | 2:1 | ||||
| 16. Ronde | 04.11.2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 17. Ronde | 17.11.2021 | H&H Export Sébaco | - | Diriangén FC | 1:1 | ||||
| 18. Ronde | 20.11.2021 | H&H Export Sébaco | - | Real Madriz | 2:3 |
Argentinië