| 2. Ronde | 13.02.2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 3. Ronde | 21.02.2022 | Club Olimpia | - | Libertad | 2:2 | ||||
| 4. Ronde | 28.02.2022 | Tacuary | - | Libertad | 0:1 |  |
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| 8. Ronde | 03.04.2022 | Guaireña FC | - | Libertad | 2:3 | ||||
| 11. Ronde | 21.04.2022 | Libertad | - | Resistencia SC | 2:2 | ||||
| 13. Ronde | 30.04.2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
| 14. Ronde | 08.05.2022 | Libertad | - | Club Olimpia | 1:0 |
Paraguay