| 1. Ronde | 03.09.2022 | Willem II [U21] | - | De Graafschap [U21] | 1:3 | ||||
| 2. Ronde | 10.09.2022 | FC Emmen [U21] | - | Willem II [U21] | 2:2 | ||||
| 3. Ronde | 17.09.2022 | ADO Den Haag [U21] | - | Willem II [U21] | 1:2 | ||||
| 4. Ronde | 01.10.2022 | Willem II [U21] | - | FC Groningen [U21] | 1:4 | ||||
| 5. Ronde | 08.10.2022 | Feyenoord [U21] | - | Willem II [U21] | 6:0 |  |
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| 6. Ronde | 15.10.2022 | Willem II [U21] | - | Almere City FC [U21] | 0:0 | |
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| 7. Ronde | 22.10.2022 | PEC Zwolle [U21] | - | Willem II [U21] | 2:1 | ||||
| 8. Ronde | 29.10.2022 | Willem II [U21] | - | FC Emmen [U21] | 0:0 | ||||
| 10. Ronde | 12.11.2022 | Willem II [U21] | - | ADO Den Haag [U21] | 2:1 | ||||
| 11. Ronde | 19.11.2022 | FC Groningen [U21] | - | Willem II [U21] | 2:0 | ||||
| 12. Ronde | 26.11.2022 | Willem II [U21] | - | Feyenoord [U21] | 0:2 |
Nederland