| 2. Ronde | 12.09.2021 | Doxa Katokopias | - | Anorthosis Famagusta | 2:0 |  |
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| 4. Ronde | 25.09.2021 | Aris Limassol | - | Anorthosis Famagusta | 3:2 | ||||
| 5. Ronde | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nicosia | 2:1 | ||||
| 6. Ronde | 17.10.2021 | AEL Limassol | - | Anorthosis Famagusta | 2:1 | ||||
| 7. Ronde | 25.10.2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 |  |
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| 8. Ronde | 29.10.2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 10. Ronde | 20.11.2021 | Olympiakos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 11. Ronde | 29.11.2021 | Anorthosis Famagusta | - | Apollon Limassol | 1:1 | ||||
| 12. Ronde | 04.12.2021 | Anorthosis Famagusta | - | PAEEK | 2:3 | ||||
| 13. Ronde | 13.12.2021 | Anorthosis Famagusta | - | Doxa Katokopias | 2:0 |  |
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| 14. Ronde | 18.12.2021 | Ethnikos Achna | - | Anorthosis Famagusta | 0:2 | ||||
| 1. Ronde | 22.12.2021 | PAEEK | - | Anorthosis Famagusta | 0:2 | |
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| 17. Ronde | 16.01.2022 | Anorthosis Famagusta | - | AEL Limassol | 2:1 | ||||
| 18. Ronde | 24.01.2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 | ||||
| 19. Ronde | 29.01.2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | ||||
| 20. Ronde | 06.02.2022 | Paphos FC | - | Anorthosis Famagusta | 1:1 | |
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