| 2. Ronde | 20.08.2021 | NK Osijek II | - | Dinamo Zagreb II | 1:1 | ||||
| 3. Ronde | 28.08.2021 | NK Dugopolje | - | NK Osijek II | 0:0 |  |
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| 4. Ronde | 10.09.2021 | NK Osijek II | - | NK Solin | 3:2 | ||||
| 5. Ronde | 15.09.2021 | NK Dubrava | - | NK Osijek II | 3:0 | ||||
| 6. Ronde | 19.09.2021 | NK Osijek II | - | NK Croatia Zmijavci | 1:2 | ||||
| 7. Ronde | 26.09.2021 | HNK Orijent Rijeka | - | NK Osijek II | 0:1 | ||||
| 8. Ronde | 02.10.2021 | NK Osijek II | - | NK Opatija | 0:2 | |
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| 9. Ronde | 16.10.2021 | HNK Cibalia | - | NK Osijek II | 1:0 | |
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| 12. Ronde | 07.11.2021 | NK Osijek II | - | NK Rudeš | 2:1 | |
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| 11. Ronde | 12.11.2021 | NK Inter Zaprešić | - | NK Osijek II | 2:0 | ||||
| 13. Ronde | 19.11.2021 | NK Kustošija | - | NK Osijek II | 0:0 | |
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| 14. Ronde | 27.11.2021 | NK Osijek II | - | NK Jarun | 0:0 | |
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| 26. Ronde | 02.05.2022 | NK Osijek II | - | NK Inter Zaprešić | 1:2 | ||||
| 27. Ronde | 07.05.2022 | NK Rudeš | - | NK Osijek II | 1:0 | |
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| 28. Ronde | 16.05.2022 | NK Osijek II | - | NK Kustošija | 0:1 | ||||
| 29. Ronde | 21.05.2022 | NK Jarun | - | NK Osijek II | 3:0 | ||||
| 30. Ronde | 28.05.2022 | NK Osijek II | - | NK BSK Bijelo Brdo | 1:1 |
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