| 1. Ronde | 21.08.2021 | FC Lisse | - | ACV Assen | 2:3 |  |
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| 2. Ronde | 28.08.2021 | ACV Assen | - | Hoek | 1:1 | ||||
| 3. Ronde | 04.09.2021 | VVOG | - | ACV Assen | 2:4 | ||||
| 4. Ronde | 11.09.2021 | ACV Assen | - | Sparta Nijkerk | 2:2 | ||||
| 5. Ronde | 18.09.2021 | DOVO | - | ACV Assen | 1:2 | ||||
| 6. Ronde | 25.09.2021 | ACV Assen | - | Harkemase Boys | 0:1 | ||||
| 7. Ronde | 02.10.2021 | ACV Assen | - | Ter Leede | 0:1 | ||||
| 8. Ronde | 09.10.2021 | VVSB | - | ACV Assen | 0:3 | ||||
| 9. Ronde | 16.10.2021 | ACV Assen | - | Sportlust '46 | 1:2 |  |
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| 10. Ronde | 30.10.2021 | SteDoCo | - | ACV Assen | 2:1 | ||||
| 12. Ronde | 13.11.2021 | DVS'33 | - | ACV Assen | 1:0 | ||||
| 13. Ronde | 20.11.2021 | ACV Assen | - | Staphorst | 2:1 | ||||
| 14. Ronde | 27.11.2021 | Excelsior '31 | - | ACV Assen | 3:0 | ||||
| 30. Ronde | 14.05.2022 | Staphorst | - | ACV Assen | 1:3 | ||||
| 31. Ronde | 21.05.2022 | ACV Assen | - | VVOG | 3:1 | |
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| 32. Ronde | 26.05.2022 | GOES | - | ACV Assen | 2:2 | ||||
| 33. Ronde | 28.05.2022 | ACV Assen | - | Excelsior '31 | 0:2 | ||||
| 34. Ronde | 04.06.2022 | Harkemase Boys | - | ACV Assen | 2:3 |
Nederland